Polystyrene nanoparticles of various shapes, sizes, as well as materials carrying diverse surface modification have numerous technological and biomedical applications. Yet the mechanism by which nano particles interact with biological structures and their biological impact and hazards remain poorly investigated.
Due to their large surface to volume ratio, Polystyrene nanospheres or particles usually exhibit properties that vary from those of bulk materials. Particularly, the surface chemistry of the nanoparticles is very important for their sturdiness as well as solubility in biological media as well as for their bio-compatibility and bio-distribution. Polystyrene does not mortify in the cellular environment and displays no short-term cytotoxicity.
As polystyrene nanoparticles easily synthesised in an extensive range of sizes with discrete surface functions. They perfectly suited as model particles to study the effects of the particle surface features on diverse biological parameters.
Action of Polystyrene nano particles
Nano-sized polystyrene materials are promising tools for new technologies in industrial, pharmaceutical as well as medical applications. On the other hand, nanoparticles may cause difficult cellular events ranging from acute cytotoxicity, induction of inflammation to genetoxic effects. Even if acute different cellular effects are not as obvious as, for example cell death and inhibition of proliferation, biopersistance and accumulation of NPs may interfere with the physiological function of cells as well as organs.
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